Effect of Eleutherine americana (aubl.) Merr ethanol extracts against high lipid profile and arterial stiffness in high-fat high-cholesterol diet-induced rats
Bibliographic record
Abstract
Comprehensive studies have been carried out on Dayak onion (Eleutherine americana (aubl.) Merr) and its effects on cardiovascular health, specifically on dyslipidemia. However, its effect in relation to arterial stiffness has not been well-studied. This study aims to assess the impact of ethanol extracts of E. americana on high cholesterol levels and arterial stiffness in an animal model with dyslipidemia generated by a high-fat high-cholesterol (HFC) diet. Daily dosages of E. americana at 25, 50, and 100 mg/kg body weight (BW) were administered to the rats for 60 days and their lipid profile, arterial stiffness, heart rate (HR), and histopathology were measured and compared to rats receiving no treatment (negative control) and simvastatin at 1.8 mg/kg BW (positive control). The results indicated that an HFC diet increases the likelihood of cardiovascular issues by raising lipid levels and encouraging the progression of atherosclerosis. This then leads to an increase in arterial stiffness and HR. The ethanol extract of E. americana successfully prevented the rise in lipid profiles and the progression of atherosclerosis, hence preventing HR from increasing and arterial stiffness. The highest effective dosage of E. americana was 100 mg/kg BW, with 50 mg/kg BW yielding similar performance to 1.8 mg/kg BW of simvastatin.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".