Endotheliales Ephrin-B2 beeinflusst die Widerstandsfähigkeit der Blut-Rückenmarksschranke in der akuten Phase nach traumatischer Rückenmarksverletzung
Bibliographic record
Abstract
Hintergrund: Die Verletzung der Blut-Rückenmarksschranke (BSCB) ist maßgeblich an der Pathophysiologie der traumatischen Rückenmarksverletzung (RMV) beteiligt. Wir konnten bereits zeigen, dass das Zell-Zell-Protein Ephrin-B2 speziell in Endothelzellen (EC) die pathologische Permeabilität der BSCB in der akuten Verletzungsphase verstärkt. Die zugrundeliegenden Mechanismen und die Auswirkungen im Langzeitmodell sind noch unbekannt. Ziel dieser Studie ist, den Einfluss von Ephrin-B2 in EC auf die strukturelle und zelluläre Integrität der BSCB sowie die neurologische Erholung nach traumatischer RMV in einem Maus-Modell bis in die chronische Phase zu untersuchen. Publication History Article published online: 13 February 2025 © 2025. Thieme. All rights reserved. Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".