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Familial Recurrence of Autism: Updates From the Baby Siblings Research Consortium

2025· article· en· W4407671400 on OpenAlexfundno aff
Sally Ozonoff, Gregory S. Young, Jessica Bradshaw, Tony Charman, Katarzyna Chawarska, Jana M. Iverson, Cheryl Klaiman, Rebecca Landa, Nicole M. McDonald, Daniel S. Messinger, Rebecca J. Schmidt, Carol L. Wilkinson, Lonnie Zwaigenbaum

Bibliographic record

VenueObstetrical & Gynecological Survey · 2025
Typearticle
Languageen
FieldPsychology
TopicFamily and Disability Support Research
Canadian institutionsnot available
FundersMedical Research CouncilAutism SpeaksEmory UniversityUniversity of TorontoChildren's Hospital FoundationNational Institutes of HealthStollery Children’s Hospital FoundationSchool of Medicine, Emory UniversityUniversity of California, Los AngelesServierUniversity of South CarolinaHarvard UniversityGeorgia Research AllianceCanadian Institutes of Health ResearchUniversity of WashingtonUniversity of Southern CaliforniaSimons Foundation Autism Research Initiative
KeywordsMedicineAutismPediatricsPsychiatry

Abstract

fetched live from OpenAlex

(Abstracted from Pediatrics 2024;154:e2023065297) Previous studies have shown that children with an older sibling diagnosed with autism spectrum disorder (ASD) face a 7- to 14-fold higher risk of receiving an ASD diagnosis themselves. This information is valuable for clinicians and families, enabling earlier counseling, planning, and diagnostic surveillance.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.066
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Insufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.088
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0060.066
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.004
Science and technology studies0.0000.002
Scholarly communication0.0000.000
Open science0.0020.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0090.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.178
GPT teacher head0.438
Teacher spread0.260 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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