PRV-1 Virulence in Atlantic Salmon Is Affected by Host Genotype
Bibliographic record
Abstract
Heart and skeletal muscle inflammation (HSMI) is a significant disease affecting Atlantic salmon (Salmo salar) production in Norway but has had limited impact to production in North America. The causative agent of HSMI is piscine orthoreovirus genotype 1 (PRV-1), and disease variation between regions is suggested to be at least partially driven by genetic variation of the virus. Using controlled laboratory injection challenges, we corroborate variations in disease outcomes for three PRV-1 isolates (PRV-1a from the eastern Pacific, PRV-1a from the western Atlantic, and PRV-1b from the Norwegian sea); however, virus replication dynamics, host recognition, and PRV-1-associated heart inflammation were also discrete relative to the Atlantic salmon stock challenged, irrespective of the viral isolate used. Specifically, New Brunswick Tobique River Atlantic salmon had less (p < 0.01) heart inflammation relative to Mowi-McConnell Atlantic salmon of Western Canada which, in turn, had less (p < 0.01) heart inflammation than Mowi Atlantic salmon of Scotland when cumulatively considering challenges using all three PRV-1 isolates. These data indicate that the presence of PRV-1a or PRV-1b alone is not sufficient to reliably predict disease and highlights at least one potential mechanism (host genotype) for reducing HSMI disease severity.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".