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Record W4407793190 · doi:10.1111/ejn.70013

Cerebral Lateralization During Handwritten and Typed Word Generation: A Functional Transcranial Doppler Ultrasound Study in Left‐Handers and Right‐Handers

2025· article· en· W4407793190 on OpenAlexaff
Christos Samsouris, Αναστασία-Κωνσταντίνα Παπαδοπούλου, Nicholas A. Badcock, Filippos Vlachos, Phivos Phylactou, Μαριέττα Παπαδάτου-Παστού

Bibliographic record

VenueEuropean Journal of Neuroscience · 2025
Typearticle
Languageen
FieldNeuroscience
TopicHemispheric Asymmetry in Neuroscience
Canadian institutionsParkwood InstituteWestern University
FundersHellenic Foundation for Research and Innovation
KeywordsLateralization of brain functionHandwritingPsychologyTranscranial DopplerAudiologyLateralityCognitive psychologyNeuroscienceMedicineComputer scienceArtificial intelligenceCardiology

Abstract

fetched live from OpenAlex

Cerebral lateralization of written language, much like oral language, is predominantly left lateralized. However, handwriting has been the primary focus in lateralization studies. The cerebral lateralization of typing-a widely used method of writing-remains unexamined. This preregistered study aimed to explore the cerebral lateralization of typing versus handwriting and to investigate possible handedness-related differences. We hypothesized that (i) cerebral lateralization would not differ between the two writing methods after movement correction and (ii) both handwriting and typing would show weaker lateralization in left-handers compared to right-handers. To investigate this, we used functional transcranial Doppler (fTCD) ultrasound, a reliable method for assessing cerebral lateralization during language tasks that remains unaffected by movement artifacts, such as those generated by handwriting and typing. A total of 24 left-handers and 30 right-handers participated, performing written word generation through both handwriting and typing on a computer keyboard while undergoing fTCD assessment. We applied a Bayesian framework for our analysis, as it enables us to demonstrate the absence of a difference (i.e., no difference between two variables), which is not possible with the use of p values (estimated under the frequentist framework). Our results provided evidence supporting the absence of a difference in cerebral lateralization between handwriting and typing after movement correction. However, we found no conclusive evidence to either support or refute a difference in lateralization between left-handers and right-handers, suggesting that more research is needed to clarify the role of handedness in cerebral lateralization for different writing methods.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.920
Threshold uncertainty score0.798

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.257
Teacher spread0.225 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes1
Has abstractyes

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