Modulatory Effects of <i>Ophiocordyceps sinensis</i> Mycelia on Hepatosteatosis Development in a High‐Fat Dietary Habit
Bibliographic record
Abstract
The global rise in obesity is closely associated with the increasing prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndromes, posing significant health challenges. This study explored the ameliorative effects of Ophiocordyceps sinensis mycelia (TCM-NA01 formula: 1.4 mg adenosine and 55.2 mg polysaccharide/capsule) on hepatosteatosis development in a high-fat diet (HFD)-fed mice. TCM-NA01 supplementation significantly reduced (p < 0.05) body weight, adipose tissue, serum triglyceride (TG)/cholesterol (TC), aspartate aminotransferase (AST), and alanine aminotransferase (ALT), liver TG/TC levels in HFD-fed mice. Increased (p < 0.05) fecal-lipid and bile-acid outputs were observed. Apparent reductions in lipid-droplet and steatosis scores (p < 0.05) in the HFD-fed mice supplemented with TCM-NA01. Furthermore, TCM-NA01 modulated lipid metabolism by decreasing fatty acid synthesis and promoting fatty acid β-oxidation. TCM-NA01 also enhanced liver antioxidant capacity and decreased proinflammatory cytokines (p < 0.05). These findings underscore the potential of O. sinensis mycelia as a nutraceutical agent for alleviating hepatosteatosis, liver oxidative stress, and chronic inflammation, offering a promising strategy for the management of obesity and NAFLD.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".