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Record W4407827460 · doi:10.1007/s11357-025-01509-9

International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus

2025· article· en· W4407827460 on OpenAlexaff
Emma Short, Robert Huckstepp, Kambiz N. Alavian, Winfried M. K. Amoaku, Thomas M. Barber, Edwin J.R. van Beek, E W Benbow, Sunil Bhandari, Philip Bloom, Carlo Cota, Paul L. Chazot, Gary Christopher, Marco Demaria, Jorge D. Erusalimsky, David A. Ferenbach, Thomas C. Foster, Gus Gazzard, Richard J. Glassock, Nadim El Jamal, Raj N. Kalaria, Venkateswarlu Kanamarlapudi, Adnan Khan, Yamini Krishna, Christiaan Leeuwenburgh, Ian van der Linde, Antonello Lorenzini, Andrea B. Maier, Reinhold J. Medina, Cecilia Luisa Miotto, Abhik Mukherjee, Krishna Mukkanna, James T. Murray, Alexander Nirenberg, Donald B. Palmer, Graham Pawelec, Venkat Reddy, Arianna Carolina Rosa, Andrew D. Rule, Paul G. Shiels, Carl Sheridan, Jeremy J. Tree, Dialechti Tsimpida, Zoe C Venables, Jack Wellington, Stuart Calimport, Barry L. Bentley

Bibliographic record

VenueGeroScience · 2025
Typearticle
Languageen
FieldMedicine
TopicTelomeres, Telomerase, and Senescence
Canadian institutionsHealth Sciences North
FundersBiotechnology and Biological Sciences Research Council
KeywordsConsensus conferenceAgeingSenescenceGerontologyMedicineInternal medicine

Abstract

fetched live from OpenAlex

Senescence definitions: ICCARP consensusWith the global increase in ageing populations, a clear understanding of the physiological and pathological changes associated with ageing is vital for advancing research and clinical practice.Following the World Health Organization's decision to classify age-related aetiologies [1], the International Consortium to Classify Ageing-related Pathologies (ICCARP) was established in 2023, led by Cardiff Metropolitan University [2].The aim of the ICCARP is to develop a systematic and comprehensive classification system for ageingrelated changes including pathologies, diseases, and syndromes.Currently, the ICCARP is in the process Emma Short and Robert TR Huckstepp are Joint first authors.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.081
metaresearch head score (Gemma)0.087
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.081
Threshold uncertainty score0.429

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0810.087
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.005
Bibliometrics0.0140.010
Science and technology studies0.0040.003
Scholarly communication0.0080.005
Open science0.0080.011
Research integrity0.0040.010
Insufficient payload (model declined to judge)0.0020.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.046
GPT teacher head0.316
Teacher spread0.270 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes1
Has abstractyes

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