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Single case study of improving differentiation of self and psychological well-being of patients with Hereditary Sensory Autonomic Neuropathy-2 using Mode Deactivation Therapy

2025· preprint· en· W4407828760 on OpenAlexaboutno aff
Arash Jelodari, Fatemeh Sadat Marashian, Laleh Hosseini, Joan Swart

Bibliographic record

Venuenot available
Typepreprint
Languageen
FieldMedicine
TopicHeart Rate Variability and Autonomic Control
Canadian institutionsnot available
Fundersnot available
KeywordsSensory systemAutonomic neuropathyMedicineSensory neuropathyPsychologyNeuroscienceInternal medicineBiologyGenetics

Abstract

fetched live from OpenAlex

The current research aimed to examine the effectiveness of the Mode Deactivation Therapy (MDT) on improving differentiation of self and psychological well-being of patients with HSAN-2. The research design was semi-experimental single case with multiple baselines. The statistical population of the research included 50 patients with HSAN2 all over the world from whom 2 were recruited (one from Iran and one from Canada) using purposive sampling method with inclusion-exclusion criteria. The patients filled out Skowron & Friedlander’s (1998) Differentiation of Self Inventory and Ryff’s (1989) Psychological Well-Being Questionnaire. The data were analyzed using clinical significance, visual inspect, diagnostic improvement and the six indices of efficacy. According to the results, the total percentage of improvement for differentiation of self and psychological well-being were 52.76 and 52.69, respectively. One can conclude that the Mode Deactivation Therapy (MDT) was effective in improving differentiation of self and psychological well-being of the patients with HSAN-2 through identifying maladjustment core beliefs and replacing them with useful alternatives via the VCR process.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Case report · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.041
GPT teacher head0.284
Teacher spread0.243 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designCase report
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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