Dynamics of Tunga penetrans infections and severity of associated morbidity among pigs during the dry season in rural Uganda
Bibliographic record
Abstract
BACKGROUND: Tungiasis is a neglected tropical disease which is common in impoverished communities. In sub-Saharan Africa, it is caused by female sand fleas, Tunga penetrans, and pigs are amongst the major domestic animal reservoirs. Depending on the environment, tungiasis occurs throughout the year or preferentially in the dry seasons. This study investigated changes in sand flea abundance and associated morbidity in pigs during a dry season. METHODS: Tunga penetrans lesions were counted and staged in 35 pigs amongst 22 households with at least one affected pig. Five weekly examinations were performed per animal during a dry season. Enrolment of pigs into the study lasted 17 days and examination was performed for 43 days. The severity score for acute pig tungiasis (SSAPT) was determined for each visit. Generalised linear mixed models (GLMM) were fitted on an absolute time scale to understand factors influencing the changes in abundance of sand flea lesions and SSAPT. RESULTS: The prevalence/abundance of tungiasis-associated lesions increased from 57.1%/median 1 lesion at baseline to 71.4%/median 11 lesions after 4 weeks. In parallel, the median SSAPT increased from zero to six. The GLMM analyses fitting negative binomial models to the lesion numbers revealed that time had a linear and a quadratic effect for the viable stages 2 and 3a, and all viable sand flea stages in general with maximal abundance of sand fleas on days 17-18, 33 and 35 from the beginning of the study, respectively. The model for the total number of sand flea lesions, which included dead and excoriated sand fleas, showed the same trend but the peak was not reached within the study period. The number of stage 3b lesions was unexpectedly low. The SSAPT increased linearly over time and was highly dependent on the initial number of sand fleas at enrolment. CONCLUSIONS: There were increasing intensities of sand fleas and SSAPT in domestic pigs during the dry season. The ensuing environmental contamination by off-host stages of T. penetrans increases the risk of transmission to other susceptible hosts, including humans.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".