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Biophysical versus machine learning models for predicting rectal and skin temperatures in older adults

2025· article· en· W4407857815 on OpenAlexafffund
Connor Forbes, Alberto Coccarelli, Zhiwei Xu, Robert D. Meade, Glen P. Kenny, Sebastian Binnewies, Aaron J. E. Bach

Bibliographic record

VenueJournal of Thermal Biology · 2025
Typearticle
Languageen
FieldMedicine
TopicThermoregulation and physiological responses
Canadian institutionsUniversity of Ottawa
FundersCanadian Institutes of Health ResearchHealth CanadaWellcome Trust
KeywordsRectal temperatureSkin temperatureArtificial intelligenceMachine learningEnvironmental scienceBiologyComputer scienceMedicineAnimal scienceBiomedical engineering

Abstract

fetched live from OpenAlex

This study compares the efficacy of machine learning models to traditional biophysical models in predicting rectal (T re ) and skin (T sk ) temperatures of older adults (≥60 years) during prolonged heat exposure. Five machine learning models were trained on data using 4-fold cross validation from 162 day-long (8–9h) sessions involving 76 older adults across six environments, from thermoneutral to heatwave conditions. These models were compared to three biophysical models: the JOS-3 model, the Gagge two-node model, and an optimised two-node model. Our findings show that machine learning models, particularly ridge regression, outperformed biophysical models in prediction accuracy. The ridge regression model achieved a Root-Mean Squared Error (RMSE) of 0.27 °C for T re , and 0.73 °C for T sk . Among the best biophysical models, the optimised two-node model achieved an RMSE of 0.40 °C for T re , while JOS-3 achieved an RMSE of 0.74 °C for T sk . Of all models, ridge regression had the highest proportion of participants with T re RMSEs within clinically meaningful thresholds at 70% (<0.3 °C) and the highest proportion for T sk at 88% (<1.0 °C), tied with the JOS-3 model. Our results suggest machine learning models better capture the complex thermoregulatory responses of older adults during prolonged heat exposure. The study highlights machine learning models' potential for personalised heat risk assessments and real-time predictions. Future research should expand upon training datasets, incorporate more dynamic conditions, and validate models in real-world settings. Integrating these models into home-based monitoring systems or wearable devices could enhance heat management strategies for older adults. • Evaluated core and skin prediction model performance under various heat conditions. • Used 162 heat exposure sessions (up to 540 min) in 76 older adults. • Machine learning models outperform biophysical models for core and skin predictions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.910
Threshold uncertainty score0.202

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.308
Teacher spread0.289 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes2
Has abstractyes

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