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Record W4407933675 · doi:10.1016/j.brs.2024.12.561

Influence of Biological Sex on the Efficacy of Neurostimulation in the Treatment of Major Depressive Disorder

2025· article· en· W4407933675 on OpenAlexaff
Marie-Claude Desjardins, Arthur R. Chaves, Jennifer Cuda, Stacey Shim, Jessica Drodge, Youssef Nasr, Ram Brender, Ruxandra Antochi, Lisa McMurray, Caroline Blais, Sara Tremblay

Bibliographic record

VenueBrain stimulation · 2025
Typearticle
Languageen
FieldNeuroscience
TopicTryptophan and brain disorders
Canadian institutionsRoyal Ottawa Mental Health CentreMental Health Research CanadaUniversity of OttawaUniversité du Québec en Outaouais
Fundersnot available
KeywordsNeurostimulationMajor depressive disorderMedicinePsychologyClinical psychologyNeuroscienceStimulation

Abstract

fetched live from OpenAlex

results support the hypothesis that individuals with lower performances in the targeted function can benefit more from the stimulation.As a quality control, individualized modeling based on brain anatomy and electrode positions confirmed good targeting of the striatum.Overall, this study highlights the promising potential of tTIS to support the recovery of impaired learning and motor functions.These proof-of-concept findings might pave the way toward developing striatal tTIS as an interventional clinical strategy to enhance learning and memory in brain-lesioned patients.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.819
Threshold uncertainty score0.223

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.309
Teacher spread0.276 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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