Enhancing Antiepileptic Drug Efficacy through Focused Ultrasound in an Epilepsy Model
Bibliographic record
Abstract
Montreal Cognitive Assessment.Secondary measures included response rate of Montreal Cognitive Assessment and changes in the Wechsler Memory Scale, Wechsler Adult Intelligence Scale, and Mini-Mental State Examination at the end of treatment.Results: Of forty-five randomized participants, forty-one were analyzed.Both the high-dose (estimated difference4.65,p<0.0001, 95% confidence interval3.31-5.99)and low-dose (estimated difference2.15,p0.0024, 95% confidence interval0.81-3.50)treatment groups showed significant improvements in Montreal Cognitive Assessment scores.Particularly, the high-dose group demonstrated better cognitive recovery and a higher recovery rate than the low-dose and sham groups, indicating a dosedependent effect for post-stroke cognitive recovery.Moreover, dosedependent improvements were similarly observed in Wechsler Memory Scale, Wechsler Adult Intelligence Scale and Mini-Mental State Examination, suggesting a consistent dose-dependent effect on memory, intelligence, and mental state.Importantly, no serious adverse events were reported. Conclusion:This study highlights dose-dependent effects in the cognitive recovery post-stroke through intermittent theta burst stimulation targeting the individualized frontoparietal network.Importantly, high-dose intermittent theta burst stimulation was found to be safe and effective for patients with post-stroke cognitive impairments.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".