Acetylcholinesterase and monoamine oxidase inhibitory activities of <i>Pistacia falcata</i> Becc. ex Martelli extract
Why this work is in the frame
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Bibliographic record
Abstract
Plants in the genus Pistacia represent valuable natural resources for neuroprotective research based on ethnomedicinal knowledge. While other Pistacia species have been extensively studied, Pistacia falcata (P. falcata) has received limited attention. This study aimed to characterise the phenolic compounds in P. falcata extract using HPLC-DAD-MS/MS and evaluate its neuroprotective potential by assessing its ability to inhibit important central nervous system (CNS) enzymes—acetylcholinesterase (AChE) and monoamine oxidases (MAO-A and MAO-B). P. falcata displayed a rich profile of phenolic acids and unique glucuronidated flavonoids, contributing to its potent antioxidant activity (IC50 23.37 ± 0.63 µg/mL). The extract exhibited a stronger inhibitory effect on MAO-B than MAO-A and inhibited AChE (IC50 0.22 ± 0.01 mg/mL). These findings suggest that P. falcata has significant neuroprotective potential, warranting further investigation as a source of functional food and nutraceutical ingredients for managing neurodegenerative diseases.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it