Invasive Respiratory Support in Critical Pediatric Asthma
Bibliographic record
Abstract
In the United States and Canada, severe asthma requiring mechanical ventilation has declined over the past decade reflecting a rise in noninvasive therapies. When aggressive noninvasive therapies fail, endotracheal intubation and mechanical ventilation are lifesaving and should be planned for in advance. As speed is important, the most experienced practitioner should intubate and rapid correction of hypercarbia and respiratory acidosis should be avoided. An elevated minute ventilation may cause pulmonary hyperinflation leading to air-leak syndrome and/or hemodynamic instability. Patients with severe air flow obstruction in asthma typically have near-normal respiratory system compliance. Therefore, an increase in plateau pressure (P plat ) usually reflects dynamic hyperinflation. A suggested upper limit for P plat is 25–30 cm H 2 O. Intrinsic PEEP (PEEPi) is measured with an expiratory hold and is valuable in that PEEP set on the ventilator can be lower than PEEPi. A reasonable ventilation strategy involving low ventilator rates and PEEP without quick correction of blood gases should be adopted. Alternative modalities to conventional mechanical ventilation are limited and unless very experienced with high-frequency oscillatory ventilation, the risk likely outweighs benefit. Heliox may be beneficial but cannot be delivered by every ventilator and this varies by manufacturer. Inhaled anesthetics are direct bronchodilators and likely beneficial but as no conventional ICU ventilator can deliver them, close cooperation with Anesthesiology is needed. Extracorporeal membrane oxygenation (ECMO) is a rescue therapy that is particularly useful in cases of severe air-leak syndrome. As with mechanical ventilation, ECMO does not reverse the asthma disease process but allows support of the patient until there is improvement with other therapies. Most children who die experience cardiac arrest prior to hospitalization. Otherwise, most mechanically ventilated children survive to hospital discharge but there is a suggestion of additional mortality from asthma in the following decade.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".