Photobleaching of Light-Activated Porphyrin-Functionalized Plastic Coupons for Potential Antimicrobial Applications
Bibliographic record
Abstract
High Resolution Image Download MS PowerPoint Slide Developing greener alternatives for harmful conventional cleaning agents is an important focus for preventing negative impacts on both the environment and human health. One potential alternative of interest is photodynamic inactivation (PDI), where a photosensitizing molecule is used to generate singlet oxygen ( 1 O 2 ) and other reactive oxygen species (ROS). ROS, 1 O 2 in particular, are known to react with cellular membranes of bacteria, resulting in cellular death. Porphyrinoids are one of these known light sensitizing species. In this work, zinc(II) 5,10,15,20-tetrakis(( N -4-[3-(trifluoromethyl)-3 H -diazirin-3-yl]benzyl)-4-pyridyl)-21 H,23 H -porphine tetrabromide is covalently attached to polyethylene terephthalate (PET) via thermal activation of a diazirine to initiate a C–H insertion. With the porphyrin now covalently bonded to the PET, the functionalized PET was assessed at a range of light intensities on its ability to generate 1 O 2 and for antimicrobial activity against Escherichia coli; the results were found to be correlated. Because photobleaching and resultant loss of activity are one of the weaknesses of PDI, the material was further assessed for its ability to withstand various photobleaching conditions. The photobleaching conditions assessed were high intensity light in dry and underwater conditions and ambient light, along with a set of dark controls. Results indicate that after 2 weeks of high intensity irradiation, the material still mediates singlet oxygen generation, albeit less efficiently. This shows promise for the use of this approach as an alternative to conventional cleaning agents.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".