Deep Few-Shot Network for Protein Family Classification: Bridging the Gap Between Limited Data and High Performance
Why this work is in the frame
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Bibliographic record
Abstract
Protein sequence analysis presents a significant challenge in bioinformatics, impacting applications such as disease investigation and precision medicine. Despite advancements in sequencing technologies and the resultant proliferation of databases, classifying protein families remains a hurdle. This study introduces a novel deep few-shot network specifically designed for protein family classification, addressing the limitations of traditional methods by utilizing deep learning with sparse training datasets. Our experiments show that this framework outperforms state-of-the-art baseline models, achieving 97.3 % precision and 95.2 % recall on the training set, and 95.0 % precision and 93.5 % recall on the test set, when trained with only 25 shots per class. This work represents the first endeavor in crafting a deep network tailored for primary sequence family classification, achieving remarkable performance with minimal observations.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it