Sublethal 6PPD-quinone exposure impairs swimming performance and aerobic metabolism in juvenile lake trout (Salvelinus namaycush)
Bibliographic record
Abstract
6PPD-quinone, an environmental oxidation product of the rubber tire antioxidant 6PPD, has recently gained recognition as a chemical of concern. Frequently detected in road runoff and surface waters, studies have reported this compound to cause acute lethality in several salmonid species at extremely low concentrations, including lake trout ( Salvelinus namaycush ; 24-h LC 50 = 0.51 μg/L). Following exposure, species experiencing acute lethality show characteristic symptoms such as gasping, spiraling, increased ventilation, loss of equilibrium, erratic movements, and tumbling. However, there is a deficit of research targeted at understanding sublethal toxicities of 6PPD-quinone exposure, particularly concerning swimming capability and metabolic function. To evaluate these effects, juvenile lake trout were exposed for 20 h to a measured concentration of 0.46 μg/L 6PPD-quinone in a swim tunnel respirometer to assess temporal changes in standard metabolic rate (SMR) compared to controls. Following exposure, fish underwent a swim trial to determine critical swimming speed (U crit ), oxygen consumption rate (MO 2 ), active metabolic rate (AMR), aerobic scope (AS) and energetic cost of transport (CoT), followed by analysis of muscle triglyceride and glycogen concentrations. Results showed that 6PPD-quinone exposure impaired swimming performance, evident by a decrease in U crit . Additionally, exposure resulted in decreased AMR, although alterations in SMR were not observed. Decreased concentrations of muscle triglycerides of swam fish were also observed. These findings suggest that environmentally relevant concentrations of 6PPD-quinone disrupt aerobic metabolic capacity in juvenile lake trout, producing adverse effects that diminish endurance and maximum swim speeds, which may affect survival of fish populations. • 6PPD-quinone exposure impairs aerobic metabolism and swimming in lake trout. • Active metabolic rate decreased significantly in exposed fish. • Standard metabolic rate was not altered in exposed fish. • Reduced U crit and abnormal swimming behaviors observed in exposed fish. • 6PPD-quinone exposure resulted in decreased triglycerides levels in swimming fish.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".