MétaCan
Menu
Back to cohort
Record W4408167715 · doi:10.1038/s41746-025-01542-0

Red teaming ChatGPT in medicine to yield real-world insights on model behavior

2025· article· en· W4408167715 on OpenAlexaff
Crystal Chang, Hodan Farah, Haiwen Gui, Shawheen J. Rezaei, Charbel Bou-Khalil, Ye‐Jean Park, Akshay Swaminathan, Jesutofunmi A. Omiye, Akaash Kolluri, Akash Chaurasia, Alejandro Lozano, Alice Heiman, Allison Sihan Jia, Amit Kaushal, Angela Y. Jia, Angelica Iacovelli, Archer Y. Yang, Arghavan Salles, Arpita Singhal, Balasubramanian Narasimhan, Benjamin Belai, Benjamin H. Jacobson, Binglan Li, Celeste H. Poe, Chandan Sanghera, Chenming Zheng, Conor Messer, Damien Varid Kettud, Deven Pandya, Dhamanpreet Kaur, Diana Hla, Diba Dindoust, Dominik Moehrle, Ross Duncan, Ellaine Chou, Eric Lin, Fateme Nateghi Haredasht, Cheng Ge, Irena Gao, Jacob Chang, Jake Silberg, Jason Fries, Jiapeng Xu, J. Weston Jamison, John Tamaresis, Jonathan H. Chen, Joshua Lazaro, Juan M. Banda, Julie Lee, Karen Ebert Matthys, Kirsten R. Steffner, Lü Tian, Luca Pegolotti, Malathi Srinivasan, Maniragav Manimaran, Matthew Schwede, Minghe Zhang, Minh Hoai Nguyen, Mohsen Fathzadeh, Qian Zhao, Rika Bajra, Rohit Khurana, Ruhana Azam, R. W. Bartlett, Sang Truong, Scott L. Fleming, S. Varadha Raj, Solveig Behr, Sonia Onyeka, Sri Muppidi, Tarek Bandali, Tiffany Eulalio, Wenyuan Chen, Xuanyu Zhou, Ying Cui, Yuqi Tan, Yutong Liu, Nigam H. Shah, Roxana Daneshjou

Bibliographic record

Venuenpj Digital Medicine · 2025
Typearticle
Languageen
FieldMedicine
TopicArtificial Intelligence in Healthcare and Education
Canadian institutionsMcGill University
Fundersnot available
KeywordsYield (engineering)PsychologyPhysics

Abstract

fetched live from OpenAlex

Red teaming, the practice of adversarially exposing unexpected or undesired model behaviors, is critical towards improving equity and accuracy of large language models, but non-model creator-affiliated red teaming is scant in healthcare. We convened teams of clinicians, medical and engineering students, and technical professionals (80 participants total) to stress-test models with real-world clinical cases and categorize inappropriate responses along axes of safety, privacy, hallucinations/accuracy, and bias. Six medically-trained reviewers re-analyzed prompt-response pairs and added qualitative annotations. Of 376 unique prompts (1504 responses), 20.1% were inappropriate (GPT-3.5: 25.8%; GPT-4.0: 16%; GPT-4.0 with Internet: 17.8%). Subsequently, we show the utility of our benchmark by testing GPT-4o, a model released after our event (20.4% inappropriate). 21.5% of responses appropriate with GPT-3.5 were inappropriate in updated models. We share insights for constructing red teaming prompts, and present our benchmark for iterative model assessments.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.759
Threshold uncertainty score0.829

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.180
GPT teacher head0.453
Teacher spread0.273 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designOther design
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations30
Published2025
Admission routes1
Has abstractyes

Explore more

Same venuenpj Digital MedicineSame topicArtificial Intelligence in Healthcare and EducationFrench-language works237,207