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Record W4408175887 · doi:10.1152/jn.00513.2024

Cerebral blood flow in Andean children and adolescents living above 5,000 m

2025· article· en· W4408175887 on OpenAlexaff
Connor A. Howe, Samuel Vergès, Daniela Nowak‐Flück, Jack S. Talbot, Benoît Champigneulle, Émeric Stauffer, Julien V. Brugniaux, Stéphane Doutreleau, Iván Hancco, Shailesh Niroula, Aurélien Pichon, Ali M. McManus, Mike Stembridge, Philip N. Ainslie

Bibliographic record

VenueJournal of Neurophysiology · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicHigh Altitude and Hypoxia
Canadian institutionsUniversity of British Columbia, Okanagan CampusUniversity of British Columbia
Fundersnot available
KeywordsEffects of high altitude on humansCerebral blood flowHypoxia (environmental)BiologyMedicineOxygenInternal medicineAnatomyChemistry

Abstract

fetched live from OpenAlex

We have, for the first time, quantified volumetric regional and global cerebral blood flow in indigenous Andean children and adolescents living above 5,000 m in the highest city in the world. Compared with Sherpa living at moderate altitude (3,800 m), and lowlanders residing at sea level, Andeans present with similar global cerebral blood flow, but lower posterior flow despite being more hypoxemic. Similar to adults, differences in high hemoglobin concentration may drive this pattern of cerebral blood flow.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.028
Threshold uncertainty score0.056

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.220
Teacher spread0.216 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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