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Record W4408201543 · doi:10.1016/j.wnsx.2025.100435

The rising interest of primary cilia in central nervous system malignancies: A bibliometric and altmetric analysis revealing the growth of a field

2025· article· en· W4408201543 on OpenAlexfundno aff
Erin N. Walker, Maame Obeng, Christian Kaculini, Megan Springer, Zara Shamim, Desmond Brown

Bibliographic record

VenueWorld Neurosurgery X · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic and Kidney Cyst Diseases
Canadian institutionsnot available
FundersNational Institute of Neurological Disorders and StrokeNational Natural Science Foundation of ChinaDeutsche ForschungsgemeinschaftCanadian Institutes of Health ResearchAmerican Cancer SocietyAccelerate Brain Cancer CureNational Institute for Health and Care ResearchAmerican Brain Tumor AssociationNational Institutes of HealthU.S. Department of Health and Human Services
KeywordsCiliumField (mathematics)BibliometricsCentral nervous systemGeographyNeuroscienceBiologyLibrary scienceComputer science

Abstract

fetched live from OpenAlex

Primary cilia have been implicated in a myriad of central nervous system malignancies. Despite the bleak prognoses of these diseases, remarkable advancements are being made to understanding the molecular mechanisms of primary cilia as a modulator in these diseases. To better comprehend the present academic endeavors in this neuro-oncology domain, we examined and assessed bibliometric and altmetric features of the primary cilia articles as they pertain to primary CNS malignancies. All primary journal articles regarding primary cilia and central nervous system (CNS) tumors were acquired by searching the Clarivate Analytics’ Web of Science Core Collection (WoSCC) and Pubmed searches. Bibliometric and altmetric analyses, data cleanup, and data visualization were conducted using InCites, Altmetric Explorer and VOSviewer. Funding information was obtained from the NIH RePORTER database. The WoSCC search yielded 133 unique articles that met the study criteria, and 45 additional articles were acquired from Pubmed searches and integrated into WoS resulting a total of 178 articles analyzed. The 10 most-cited articles were also evaluated. For this study, all articles were generated within the United States and published by a total 42 journals. As the role of primary cilia in CNS cancer continues to be explored, the amount of funding allocated, and publications released steadily increases annually. The findings provided by basic science articles drive our understanding of primary cilia as they relate to neuro-oncology. Bibliometric and altimetric analyses are significant contributors in the comprehension of current literature and for the identification of knowledge gaps. Ultimately these analyses encourage future research pursuits in the creation of ciliotherapies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesBibliometrics
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.124
Threshold uncertainty score0.997

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0050.024
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.235
Teacher spread0.223 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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