Bibliographic record
Abstract
Pemphigus Vulgaris (PV) is an autoimmune blistering disease that is characterized by painful erosions and flaccid blisters involving the mucous membranes and skin (Figure 1). The production of pathogenic immunoglobulin autoantibodies, mainly IgG4, against the desmosomal cadherins desmoglein 1 (Dsg-1) and desmoglein 3 (Dsg‑3), lead to the loss of epidermal keratinocyte adhesion. In the mucosal dominant type, Dsg-3 antibodies are present, while in the mucocutaneous type, antibodies against both desmoglein 1 and 3 are found. Diagnosing PV requires compatible clinical features, histopathological examination of the involved skin, and the detection of autoantibodies by indirect immunofluorescence of non-affected peri-lesional skin. The pemphigus disease area index (PDAI) and the autoimmune bullous skin disorder intensity score (ABSIS) provide a standardized assessment of disease extent and response to treatment. A treatment algorithm has been proposed for PV (Figure 2 and Figure 3). In addition, supportive management is also important (Table 1).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.004 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.010 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".