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Record W4408280255 · doi:10.1021/acsnano.4c10525

Interfacing with the Brain: How Nanotechnology Can Contribute

2025· review· en· W4408280255 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueACS Nano · 2025
Typereview
Languageen
FieldNeuroscience
TopicNeuroscience and Neural Engineering
Canadian institutionsInstitute of Cancer Research
FundersAdvanced Science InstituteCalifornia NanoSystems InstituteU.S. Naval Research LaboratoryNational Institute of Neurological Disorders and StrokeNational Institute on Drug AbuseNational Institute of Mental HealthAgencia Estatal de InvestigaciónResearch Center for Eco-Environmental Sciences, Chinese Academy of SciencesAgence Nationale de la RechercheLeibniz-GemeinschaftDeutsches Elektronen-SynchrotronJiangsu National Synergistic Innovation Center for Advanced MaterialsHorizon 2020 Framework ProgrammeNational Center for Complementary and Integrative HealthUniversity of California, DavisUniversity of California, Los AngelesNational Institutes of HealthScuola Internazionale Superiore di Studi AvanzatiInstitute for Basic ScienceUniversität Duisburg-EssenJunta de AndalucíaNanjing UniversityUniversität HamburgPasteur Institute of IranFundacja na rzecz Nauki PolskiejAmerican Society for Engineering EducationBundesministerium für Bildung und ForschungChina Scholarship CouncilConsejería de Conocimiento, Investigación y Universidad, Junta de AndalucíaUniversitat Rovira i VirgiliFraunhofer-GesellschaftNational Science FoundationBundesanstalt für Materialforschung und -PrüfungEidgenössische Technische Hochschule ZürichYonsei UniversityConsejo Nacional de Ciencia y TecnologíaCentro de Investigación Biomédica en Red sobre Enfermedades NeurodegenerativasUniversity of Chinese Academy of SciencesCarl-Zeiss-StiftungHangzhou Normal UniversityDivision of Materials ResearchEuropean Regional Development FundCentre National de la Recherche ScientifiqueDeutsche ForschungsgemeinschaftChinese Academy of SciencesJane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los AngelesAustralian GovernmentEuropean CommissionInstituto de Salud Carlos IIINanyang Technological UniversityScience and Engineering Research BoardDivision of Chemical, Bioengineering, Environmental, and Transport SystemsOffice of Naval ResearchDepartment of Biotechnology, Ministry of Science and Technology, IndiaNational Institute on AgingAlexander von Humboldt-StiftungHelmholtz-Zentrum Dresden-RossendorfNanjing University of Posts and TelecommunicationsDeutscher Akademischer AustauschdienstIndian Institute of Technology Kharagpur
KeywordsInterfacingNanotechnologyApplications of nanotechnologyMaterials scienceNeuroscienceComputer sciencePsychology

Abstract

fetched live from OpenAlex

Interfacing artificial devices with the human brain is the central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain-machine interfaces have changed over time, along with the available technology. Mechanical levers and cable winches were used to move parts of the brain during the mechanical age. Sophisticated electronic wiring and remote control have arisen during the electronic age, ultimately leading to plug-and-play computer interfaces. Nonetheless, our brains are so complex that these visions, until recently, largely remained unreachable dreams. The general problem, thus far, is that most of our technology is mechanically and/or electrically engineered, whereas the brain is a living, dynamic entity. As a result, these worlds are difficult to interface with one another. Nanotechnology, which encompasses engineered solid-state objects and integrated circuits, excels at small length scales of single to a few hundred nanometers and, thus, matches the sizes of biomolecules, biomolecular assemblies, and parts of cells. Consequently, we envision nanomaterials and nanotools as opportunities to interface with the brain in alternative ways. Here, we review the existing literature on the use of nanotechnology in brain-machine interfaces and look forward in discussing perspectives and limitations based on the authors' expertise across a range of complementary disciplines─from neuroscience, engineering, physics, and chemistry to biology and medicine, computer science and mathematics, and social science and jurisprudence. We focus on nanotechnology but also include information from related fields when useful and complementary.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.955
Threshold uncertainty score0.936

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.035
GPT teacher head0.284
Teacher spread0.250 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it