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Record W4408342928 · doi:10.1002/epd2.70016

<scp>ILAE</scp> neuroimaging task force highlight: The utility of multimodal neuroimaging in diagnostic and presurgical workup of drug‐resistant focal epilepsy

2025· article· en· W4408342928 on OpenAlexaff
Niccolò Biagioli, Maksim Parfyonov, Stefano Meletti, Giacomo Pavesi, John S. Archer, Boris C. Bernhardt, Lorenzo Caciagli, Fernando Cendes, Yotin Chinvarun, Luis Concha, Paolo Federico, William D. Gaillard, Eliane Kobayashi, Godwin Ogbole, Stefan Rampp, Shuang Wang, Gavin P. Winston, Irène Wang, Anna Elisabetta Vaudano

Bibliographic record

VenueEpileptic Disorders · 2025
Typearticle
Languageen
FieldMedicine
TopicEpilepsy research and treatment
Canadian institutionsQueen's UniversityHotchkiss Brain InstituteUniversity of Calgary
FundersNational Institute of Neurological Disorders and StrokeFundação de Amparo à Pesquisa do Estado de São Paulo
KeywordsNeuroimagingMedicineModalitiesEpilepsy surgeryEpilepsyFunctional neuroimagingRadiologyNeurosciencePsychologyPsychiatry

Abstract

The ILAE Neuroimaging Task Force publishes educational case reports that highlight basic aspects of neuroimaging in epilepsy, consistent with ILAE's educational mission. In patients with drug-resistant focal epilepsy who are candidates for surgical intervention, the identification of structural abnormalities is a strong predictor of favorable postoperative seizure outcomes. When conventional imaging is insufficient, the integration of multimodal neuroimaging data with structural, metabolic, and functional imaging modalities is often helpful. The following two illustrative cases from two different centers highlight the challenges and needs to integrate the information from multiple imaging modalities for a more accurate diagnosis and resection planning of drug-resistant focal epilepsies. This approach can increase the number of patients eligible for surgery while minimizing the risk of postoperative deficits.

Stored with the screening record, where it is evidence for the labels above.

How this classification was reachedexpand

The three-model screen

all 5,600 screened works →

All three models called this out of scope.

stratum: aff_core · design weight: 5595.24 (the sample is stratified; any rate computed without the weight is wrong)
Claude Opus 4.8OUT
genre: empirical
about Canada: no
confidence: high

Educational case report on multimodal neuroimaging in presurgical epilepsy workup.

GPT-5.6 (high)OUT
genre: editorial/commentary
about Canada: no
confidence: high

It presents educational epilepsy cases about neuroimaging practice, not research practice.

Grok 4.5OUT
genre: editorial/commentary
about Canada: no
confidence: high

Educational clinical neuroimaging case reports for epilepsy care, not research practice as object.

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.013
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.014
Threshold uncertainty score0.000

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.013
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0020.002
Open science0.0010.001
Research integrity0.0040.003
Insufficient payload (model declined to judge)0.0140.008

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.268
Teacher spread0.259 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations6
Published2025
Admission routes1
Has abstractyes

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