Total Synthesis of (−)-Elodeoidins A and B
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Biomimicry has long been a valuable approach for designing efficient synthetic strategies in complex natural product synthesis. However, abiotic yet powerful transforms can significantly streamline the synthesis by introducing greater convergence to the synthetic route. Herein, we delineate a convergent total synthesis of elodeoidins A and B, enabled by a cross-dehydrogenative coupling (CDC) reaction between an aldehyde and an electron-deficient olefin. The CDC reaction operating under the newly discovered reaction conditions proceeds via distinct concerted deprotonation within the formal Cu(III) catalytic complex. Furthermore, the total synthesis of both structural candidates of elodeoidin B revealed that the natural product exists as a mixture of epimers at the C8 stereocenter.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it