Protocol for project MHISS: Mental Health and Immunodynamics of Social Stress
Bibliographic record
Abstract
Background: Growing evidence suggests that immune alterations may mediate the impact of stress on a plethora of negative psychological and somatic health outcomes. In particular, social stress has been demonstrated to be a particularly potent type of stress that modulates immune activity. Typically, this effect has been tested in the lab with acute social stressors. To build upon this research with greater external validity, we used the transition to college campuses for 1st year undergraduates as an ecologically valid social stressor in this novel, intensive longitudinal psychoneuroimmunology study. Method: This NIMH-funded study collected data from 173 incoming 1st year students at a large public university in California, USA. Eligible participants were recruited using an online screener disseminated by the University registrar's office and had to be 17-19 years old, fluent in English, living on campus, not have self-selected any roommates, and have moved at least 100 miles to campus. Enrolled participants completed a baseline survey, daily self-report measures (3589 reports total), and blood draws every three days for 22 days (656 assayed samples), as well as an additional survey on the 22nd day. The start of the daily surveys was timed so that students' 7th survey was their first full day on campus (i.e., the day after move-in). We also describe sub-studies involving (a) diagnostic interviews at the end of students' 1st academic year, (b) extending the daily surveys to capture a full month for participants with a menstrual cycle, and (c) piloting a college transition resilience program. Discussion: Consistent with recent calls from the NIMH Director, this study uses the transition to college as an ecologically valid stress paradigm, in combination with novel intensive longitudinal assessment of immunology, to characterize social stress-related changes in biopsychosocial functioning over time. Studies resulting from this project will shed light on the dynamic interplay between key psychoneuroimmunological processes, advance the methodological standards of this field, and help identify intervention opportunities to improve mental health on college campuses and beyond.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.027 | 0.035 |
| Meta-epidemiology (narrow) | 0.003 | 0.003 |
| Meta-epidemiology (broad) | 0.003 | 0.003 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.007 | 0.001 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.004 | 0.005 |
| Research integrity | 0.003 | 0.006 |
| Insufficient payload (model declined to judge) | 0.262 | 0.062 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".