Hepatitis B prevention interventions during HIV post-exposure prophylaxis visits: A retrospective chart review
Bibliographic record
Abstract
BackgroundHepatitis B virus (HBV) disproportionately affects people at risk of HIV. Encounters for HIV post-exposure prophylaxis (PEP) create opportunities for HBV screening and prevention. We quantified HBV prevalence, susceptibility, and active/passive immunization use among patients seeking HIV PEP.MethodsWe conducted a retrospective chart review of patients requesting PEP at an academic hospital between 2001-2021 in Toronto, Canada. Patients were classified as HBV immune or susceptible based on laboratory tests. Among HBV-susceptible individuals, we quantified how often HBV vaccine and/or hepatitis B immune globulin (HBIG) were administered.ResultsWe identified 2018 PEP episodes, 75.3% being for sexual exposures. Mean age was 33.6 years. Among 1593 (78.9%) participants with available HBV testing data, six (0.4%) tested HBsAg-positive. Of 2018 episodes, 56.8% were among HBV-immune and 19.8% among HBV-susceptible participants; 23.1% were among participants of unknown status. Of susceptible participants, 55 (13.8%) received HBIG and 143 (35.8%) received HBV vaccinations.ConclusionsHBV prevalence was low but roughly one-fifth of patients seeking HIV PEP were HBV-susceptible. HBIG use was inconsistent with current guidelines, and a minority of HBV-susceptible individuals were vaccinated. More systematic HBV testing, increased HBV vaccination and more rational use of HBIG are needed in those seeking HIV PEP.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".