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Record W4408364500 · doi:10.1039/d5fd00013k

Bone mineralization and the effects of elevated osteopontin: from symmetry-breaking foci to 3D space-filling tessellation

2025· article· en· W4408364500 on OpenAlexafffund
Joseph Deering, Daniel J. Buss, Roland Kröger, Hojatollah Vali, Maureen J. Lagos, Natalie Reznikov, Marc D. McKee

Bibliographic record

VenueFaraday Discussions · 2025
Typearticle
Languageen
FieldMaterials Science
TopicCalcium Carbonate Crystallization and Inhibition
Canadian institutionsMcMaster UniversityMcGill UniversityMcGill University Health Centre
FundersFonds de Recherche du Québec - SantéNatural Sciences and Engineering Research Council of CanadaEngineering and Physical Sciences Research CouncilCanadian Institutes of Health ResearchNational Institutes of HealthRéseau de Recherche en Santé Buccodentaire et OsseuseCanada Research ChairsNational Institute of Diabetes and Digestive and Kidney DiseasesMcGill University
KeywordsOsteopontinOsteoidMineralization (soil science)Tessellation (computer graphics)ChemistryAnatomyBiologyGeometryMathematics

Abstract

fetched live from OpenAlex

foci, consistent with a more amorphous mineral character, suggesting that OPN may play a role in delaying the amorphous-to-crystalline transition. These aspects of nanoscale mineral maturation in mutant mice having elevated OPN implicate this protein as a fine-tuning regulator of mineralization kinetics, mineral composition, and mechanical properties of bone.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.054
Threshold uncertainty score0.326

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.231
Teacher spread0.226 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations6
Published2025
Admission routes2
Has abstractyes

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