Impact of intermittent theta burst repetitive transcranial magnetic stimulation on irritability: A retrospective analysis of patients with major depressive disorder
Bibliographic record
Abstract
Irritability is common in major depressive disorder (MDD) and associated with poor outcomes The impact of repetitive transcranial magnetic stimulation (rTMS) for MDD on irritability is poorly explored. A retrospective analysis was conducted on 63 patients with MDD who received 20 sessions of intermittent theta burst rTMS targeting the left dorsolateral prefrontal cortex. The primary outcome was the Concise Associated Symptoms Tracking: Irritability scale (CAST-IRR). Depression symptoms were tracked using the 17-item Hamilton Depression Rating Score (HAMD-17). Mean irritability scores improved from baseline to week 4 of treatment after controlling for age, gender, depression scores, and baseline anxiety. There was greater improvement of irritability from baseline to week 4 among those who responded. Greater improvement in irritability was associated with higher odds of response at week 4. This study provides preliminary evidence that intermittent theta burst rTMS for MDD is associated with improvement in irritability that correlates with response.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.004 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".