A robust deep learning approach for segmenting cortical and trabecular bone from 3D high resolution µCT scans of mouse bone
Bibliographic record
Abstract
Recent advancements in deep learning have significantly enhanced the segmentation of high-resolution microcomputed tomography (µCT) bone scans. In this paper, we present the dual-branch attention-based hybrid network (DBAHNet), a deep learning architecture designed for automatically segmenting the cortical and trabecular compartments in 3D µCT scans of mouse tibiae. DBAHNet's hierarchical structure combines transformers and convolutional neural networks to capture long-range dependencies and local features for improved contextual representation. We trained DBAHNet on a limited dataset of 3D µCT scans of mouse tibiae and evaluated its performance on a diverse dataset collected from seven different research studies. This evaluation covered variations in resolutions, ages, mouse strains, drug treatments, surgical procedures, and mechanical loading. DBAHNet demonstrated excellent performance, achieving high accuracy, particularly in challenging scenarios with significantly altered bone morphology. The model's robustness and generalization capabilities were rigorously tested under diverse and unseen conditions, confirming its effectiveness in the automated segmentation of high-resolution µCT mouse tibia scans. Our findings highlight DBAHNet's potential to provide reliable and accurate 3D µCT mouse tibia segmentation, thereby enhancing and accelerating preclinical bone studies in drug development. The model and code are available at https://github.com/bigfahma/DBAHNet .
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".