P679: Functional studies in fibroblasts cultured from patients with inborn errors of vitamin B12 metabolism
Bibliographic record
Abstract
95% of DPD deficiencies within the population.In addition, validation of an in-house DPYD full gene sequencing is in progress to detect rare variants other than the most common ones.Results: So far, 202 cancer patients have been subjected to DPYD genotyping prior to chemotherapy.Thirteen of them were detected to have a reduced function or non-function allele, which accounts for ~6.5% in patient population.Their doses of 5-FU/capecitabine were adjusted accordingly to prevent the risk of severe side effects.Conclusion: DPYD testing allows for the early detection of DPD deficiencies, which improves patient outcomes by adjusting the dosage of fluoropyrimidine drugs used in chemotherapy treatment, overall reducing the risk of severe side effects.Local availability of these tests allows cancer patients to access safe, effective treatment much faster.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".