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Record W4408502186 · doi:10.1016/j.gimo.2025.103055

P686: Opportunistic screening for broad range of clinically relevant secondary findings: Outcomes of exome analysis in the Incidental Genomics RCT

2025· article· en· W4408502186 on OpenAlexaff
Chloe Mighton, Emma Reble, Jordan Sam, Rita Kodida, Salma Shickh, Marc Clausen, Daena Hirjikaka, Sonya Grewal, Seema Panchal, Carolyn Piccinin, Melyssa Aronson, Susan Randall Armel, Larissa Peck, Tracy Graham, Yael Silberman, Thomas Ward, José‐Mario Capo‐Chichi, Elena Greenfeld, Abdul Noor, Iris Cohn, Chantal F. Morel, Christine Elser, Andrea Eisen, Emily Glogowski, Kasmintan A. Schrader, Raymond H. Kim, Kelvin Chan, Kevin E. Thorpe, Jordan Lerner‐Ellis, Yvonne Bombard

Bibliographic record

VenueGenetics in Medicine Open · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomics and Rare Diseases
Canadian institutionsHospital for Sick ChildrenJuravinski Cancer CentreSunnybrook Health Science CentreHealth Sciences CentreUniversity of TorontoUniversity Health Network
Fundersnot available
KeywordsRandomized controlled trialExome sequencingExomeGenomicsMedicineComputational biologyBiologyGenomeGeneticsInternal medicinePhenotypeGene

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.023
Threshold uncertainty score0.440

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.371
Teacher spread0.330 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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