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Record W4408506484 · doi:10.1038/s41375-025-02558-x

The proto-oncogenic miR-106a-363 cluster enhances adverse risk acute myeloid leukemia through mitochondrial activation

2025· article· en· W4408506484 on OpenAlexafffund
Nadine Sperb, Irina A. Maksakova, Leo Escano, Libin Abraham, Liam MacPhee, Ariene Cabantog, Mansen Yu, Kathrin Krowiorz, Junbum Im, Sarah Grasedieck, Nicole Pochert, Christoph Rueß, R. Rosler, Stéphane Flibotte, Tobias Maetzig, Enrico Calzia, Lars Palmqvist, Sebastian Wiese, Linda Fogelstrand, Michael R. Gold, A. MAUREEN ROUHI, Florian Kuchenbauer

Bibliographic record

VenueLeukemia · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMicroRNA in disease regulation
Canadian institutionsUniversity of British ColumbiaTerry Fox Research Institute
FundersBarncancerfondenCancerfondenDeutsche ForschungsgemeinschaftGovernment of CanadaNatural Sciences and Engineering Research Council of CanadaDeutsche KrebshilfeWilhelm Sander-StiftungLeukemia and Lymphoma Society of CanadaCanadian Institutes of Health ResearchEuropean Hematology AssociationVästra Götalandsregionen
KeywordsMyeloid leukemiaCancer researchAdverse effectLeukemiaMedicineMyeloidImmunologyInternal medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.169
Threshold uncertainty score0.881

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.253
Teacher spread0.247 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes2
Has abstractno

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