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Record W4408598466 · doi:10.1016/s1474-4422(25)00024-9

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial

2025· article· en· W4408598466 on OpenAlexaff
Randall J. Bateman, Yan Li, Eric McDade, Jorge J. Llibre‐Guerra, David B. Clifford, Alireza Atri, Susan L. Mills, Anna Santacruz, Guoqiao Wang, Charlene Supnet, Tammie L.S. Benzinger, Brian A. Gordon, Laura Ibáñez, Gregory Klein, Monika Baudler, Rachelle S. Doody, Paul Delmar, Geoffrey A. Kerchner, Tobias Bittner, Jakub Wojtowicz, Azad Bonni, Paulo Fontoura, Carsten Hofmann, Luka Kulic, Jason Hassenstab, Andrew J. Aschenbrenner, Richard J. Perrin, Carlos Cruchaga, Alan E. Renton, Chengjie Xiong, David M. Holtzman, B. Joy Snider, Catherine J. Mummery, William S. Brooks, David Wallon, Sarah Berman, Erik D. Roberson, Colin L. Masters, Douglas Galasko, Suman Jayadev, Raquel Sánchez‐Valle, Jérémie Pariente, Justin Kinsella, Christopher H van Dyck, Serge Gauthier, Ging‐Yuek Robin Hsiung, Mario Masellis, Bruno Dubois, Lawrence S. Honig, Clifford R. Jack, Alisha Daniels, David Aguillón, Ricardo Allegri, Jasmeer P. Chhatwal, Gregory S. Day, Nick C. Fox, Edward D. Huey, Takeshi Ikeuchi, Mathias Jucker, Jae‐Hong Lee, Allan I. Levey, Johannes Levin, Francisco Lopera, Jee Hoon Roh, Pedro Rosa‐Neto, Peter R. Schofield

Bibliographic record

VenueThe Lancet Neurology · 2025
Typearticle
Languageen
FieldMedicine
TopicAlzheimer's disease research and treatments
Canadian institutionsUniversity of TorontoSunnybrook Health Science CentreHealth Sciences CentreUniversity of British ColumbiaMcGill University
FundersNational Institutes of HealthF. Hoffmann-La RocheNational Institute on AgingEli Lilly and CompanyGHR FoundationAlzheimer's AssociationFoundation for the National Institutes of Health
KeywordsPlaceboDouble blindOpen labelMedicineTerm (time)PsychiatryInternal medicinePsychologyRandomized controlled trialPhysicsAlternative medicinePathology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.061
Threshold uncertainty score0.663

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.093
GPT teacher head0.397
Teacher spread0.304 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations39
Published2025
Admission routes1
Has abstractno

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