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Record W4408667482 · doi:10.1212/wnl.0000000000213515

Endovascular Therapy for NIHSS ≤5

2025· editorial· en· W4408667482 on OpenAlexaboutno aff
Susanne G. H. Olthuis, Wim H. van Zwam

Bibliographic record

VenueNeurology · 2025
Typeeditorial
Languageen
FieldMedicine
TopicAcute Ischemic Stroke Management
Canadian institutionsnot available
Fundersnot available
KeywordsMedicine

Abstract

fetched live from OpenAlex

Since the efficacy of endovascular therapy (EVT) for ischemic stroke was established in 2015, its indications expanded considerably. The treatment time window has been extended from 6 to 24 hours from last seen well, and patients with large infarct cores and/or low Alberta Stroke Program Early CT Scores also demonstrated treatment benefit, contrary to initial expectations. In addition, patients with basilar artery occlusions - not included in the initial EVT trials - seemed to benefit from EVT as well. However, controversy persists regarding the treatment effect for patients with more distal or so-called medium vessel occlusions or with mild neurologic symptoms (defined as a National Institutes of Health Stroke Scale [NIHSS] score ≤5). For these patients, the smaller clinical improvements to be gained should be carefully weighed against the inherent potential risks of invasive treatments such as EVT. Although several randomized trials investigated treatment effects in patients with medium vessel occlusions, less attention has been paid to treatment of patients with low baseline NIHSS scores, particularly in the late window.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: Editorial
Teacher disagreement score0.009
Threshold uncertainty score0.000

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.009
Meta-epidemiology (narrow)0.0040.001
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0020.001
Science and technology studies0.0010.001
Scholarly communication0.0030.003
Open science0.0020.001
Research integrity0.0090.017
Insufficient payload (model declined to judge)0.0070.008

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.275
Teacher spread0.265 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEditorial

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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