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Record W4408695189 · doi:10.1016/j.jaac.2025.03.014

Characterizing Rare DNA Copy-Number Variants in Pediatric Obsessive-Compulsive Disorder

2025· article· en· W4408695189 on OpenAlexafffund
Emily Olfson, Carolina Cappi, Samantha Greenspun, Gwyneth Zai, Maria Conceição do Rosário, A. Jeremy Willsey, Roseli Gedanke Shavitt, Eurı́pedes Constantino Miguel, James L. Kennedy, Margaret A. Richter, Thomas Fernandez

Bibliographic record

VenueJournal of the American Academy of Child & Adolescent Psychiatry · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomic variations and chromosomal abnormalities
Canadian institutionsSunnybrook Health Science CentreCentre for Addiction and Mental Health
FundersYale Center for Clinical Investigation, Yale School of MedicineNational Center for Advancing Translational SciencesWeill Institute for Neurosciences, University of California, San FranciscoNational Institute of Mental HealthCanadian Institutes of Health ResearchRaymond and Beverly Sackler Institute for Biological, Physical and Engineering Sciences, Yale UniversityNational Institutes of HealthAmerican Academy of Child and Adolescent PsychiatryFundação de Amparo à Pesquisa do Estado de São PauloUniversidade de São PauloConselho Nacional de Desenvolvimento Científico e TecnológicoYale UniversityUniversity of TorontoNational Institute of Neurological Disorders and StrokeNew Venture FundOntario Mental Health FoundationSunnybrook Research InstituteInstituto Nacional de Psiquiatria do Desenvolvimento para Crianças e AdolescentesChild Study Center, Yale School of MedicineKlingenstein Third Generation FoundationPhysicians' Services Incorporated FoundationInstituto Nacional de Ciência e Tecnologia de NanobiofarmacêuticaGeorgia Clinical and Translational Science AllianceCentre for Addiction and Mental HealthUniversity of California, San FranciscoInternational OCD FoundationNational Alliance for Research on Schizophrenia and DepressionAllison Family FoundationTourette Association of AmericaHartwell FoundationCampbell Family Mental Health Research InstituteMisophonia Research FundBrain and Behavior Research Foundation
KeywordsObsessive compulsiveCopy-number variationGeneticsComputational biologyPsychologyBiologyPsychiatryGenomeGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0010.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.250
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes2
Has abstractno

Explore more

Same venueJournal of the American Academy of Child & Adolescent PsychiatrySame topicGenomic variations and chromosomal abnormalitiesFrench-language works237,207