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Record W4408730544 · doi:10.1016/j.vaccine.2025.127034

Alcohol consumption does not influence SARS-CoV-2 vaccine immunogenicity: A stop the spread Ottawa cohort analysis

2025· article· en· W4408730544 on OpenAlexafffundabout
Alicia Vachon, Alexa Keeshan, Yannick Galipeau, Angela M. Crawley, Marc‐André Langlois, Curtis Cooper

Bibliographic record

VenueVaccine · 2025
Typearticle
Languageen
FieldMedicine
TopicSARS-CoV-2 and COVID-19 Research
Canadian institutionsOttawa Public HealthOttawa HospitalUniversity of Ottawa
FundersCanadian Institutes of Health ResearchUniversity of Ottawa
KeywordsImmunogenicityMedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyAlcohol consumptionCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakCohortCohort studyImmunologyEnvironmental healthBiologyInternal medicineOutbreakAlcoholAntibodyInfectious disease (medical specialty)Disease

Abstract

fetched live from OpenAlex

The effect of alcohol consumption on COVID-19 vaccine immunogenicity was evaluated. Participants from the Stop the Spread Ottawa cohort were categorized by alcohol consumption categorized as excessive or non-excessive based on the Canadian Centre on Substance Abuse and Addiction's (CCSA) 2023 guidelines on alcohol use. Our analyses showed that alcohol consumption did not influence SARS-CoV-2 antibody baseline levels, post vaccine increase or decay over time.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.403
Threshold uncertainty score0.811

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.004
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0000.001
Science and technology studies0.0020.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.029
GPT teacher head0.356
Teacher spread0.327 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes3
Has abstractyes

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