Use of Antiplatelet Agents in Canadian Patients: A Reflection of the 2023 Antiplatelet Guidelines
Bibliographic record
Abstract
Antiplatelet agents play a fundamental role in secondary prevention of atherosclerotic cardiovascular disease by reducing the risk of recurrent ischemic events. Over the past decades, developments and refinements in antiplatelet therapy have been made through the commercialization of novel classes (P2Y12 inhibitors, glycoprotein [GP] IIb/IIIa inhibitors), modes of administration (oral and intravenous), and combination strategies (dual antiplatelet therapy [DAPT] of different durations). Recently, concerns have been raised regarding the prognostic impact of bleeding events associated with antiplatelet agents. Consequently, multiple strategies have been studied to optimize the fine balance between ischemic protection and bleeding avoidance with these agents. The 2023 Focused Update of the Guidelines for the Use of Antiplatelet Therapy by the Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology distilled the most recent evidence on this topic from a Canadian perspective. This review offers insights into the implementation of the guidelines’ recommendations in routine clinical practice within the Canadian setting.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".