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Record W4408790710 · doi:10.1073/pnas.2421921122

Climate change amplifies neurotoxic methylmercury threat to Asian fish consumers

2025· article· en· W4408790710 on OpenAlexaff
Mengjie Wu, Xinda Wu, Alfonso Saiz‐Lopez, Paul J. Blanchfield, Hongqiang Ren, Huan Zhong

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2025
Typearticle
Languageen
FieldEnvironmental Science
TopicMercury impact and mitigation studies
Canadian institutionsFisheries and Oceans Canada
FundersNational Natural Science Foundation of China
KeywordsMethylmercuryClimate changeFreshwater fishChinaEnvironmental scienceFisheryMercury (programming language)Environmental protectionEcologyFish <Actinopterygii>GeographyBiology

Abstract

fetched live from OpenAlex

Climate change is intricately influencing the accumulation of neurotoxic methylmercury (MeHg) in human food webs, potentially leading to uneven exposure risks across regions. Here, we reveal that climate change will elevate MeHg risks in China, with implications for regional inequalities in Asia through a climate-mercury-food-health nexus. Using a compiled fish mercury dataset from 13,000 samples and machine learning, we find that freshwater wild fish-an essential component of the Asian diet-is an underappreciated MeHg source. Specifically, MeHg concentrations in freshwater wild fish are 2.9 to 6.2 times higher than in freshwater farmed fish and 1.7 times higher than in marine wild fish. Individual climate factors influence MeHg accumulation differently, while their combined effects significantly increase MeHg concentrations in freshwater wild fish. Under SSP2-4.5 and SSP5-8.5 by 2031 to 2060, national average MeHg concentrations in freshwater wild fish are projected to increase by about 60%, adding a maximum annual economic loss of US$18 million (2022 USD) from intelligence quotient decrements in Chinese newborns. This loss may vary regionally within China and among Asian countries, disproportionately affecting less developed areas. Coordinating climate action with mercury emission reduction strategies could mitigate these overlooked regional risks, reduce regional inequalities in food safety, and ultimately contribute to sustainable development.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.073
Threshold uncertainty score0.144

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.064
GPT teacher head0.340
Teacher spread0.276 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2025
Admission routes1
Has abstractyes

Explore more

Same venueProceedings of the National Academy of Sciences→Same topicMercury impact and mitigation studies→French-language works237,207→