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Record W4408811449 · doi:10.1183/23120541.01295-2024

Lung structure and function, post-treatment, in strictly defined subclinical pulmonary tuberculosis: a prospective cohort study in Canada

2025· letter· en· W4408811449 on OpenAlexaffabout
Richard Long, Sophie É. Collins, Michael K. Stickland, Miranda Kirby, Angela Lau, J Barrié, Christopher Winter, Gavin Armstrong, Eric Wong, Anu Parhar, Jaled Yehya, Jean Bourbeau, Wan C. Tan, Alexander Doroshenko

Bibliographic record

VenueERJ Open Research · 2025
Typeletter
Languageen
FieldMedicine
TopicTuberculosis Research and Epidemiology
Canadian institutionsUniversity of British ColumbiaMcGill University Health CentreUniversity of Alberta
Fundersnot available
KeywordsMedicineSubclinical infectionProspective cohort studyCohortPulmonary tuberculosisTuberculosisLungInternal medicineCohort studyLung functionPulmonary function testingPathology

Abstract

fetched live from OpenAlex

<title>Extract</title> Pulmonary tuberculosis (PTB) may cause permanent lung injury despite microbiologic cure. Pulmonary function tests (PFTs) are recommended to assess the extent of injury. But whether measurable impairment occurs and PFTs are necessary when PTB is diagnosed early, at the strictly defined subclinical stage, is unknown. In high-income countries, most subclinical PTB is discovered during active case-finding and radiographs are normal or minimally abnormal [1]. We hypothesised that post-treatment lung structure and function in such patients, when precisely measured, would depart minimally, if at all, from that in healthy control subjects.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.305
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.004
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0010.002
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0010.008
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.052
GPT teacher head0.400
Teacher spread0.349 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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