Cronkhite-Canada disease: an infrequent diagnosis
Bibliographic record
Abstract
A 55-year-old male was admitted with constitutional syndrome and acute diarrhea. Physical examination revealed alopecia, cutaneous hyperpigmentation and onychodystrophy. Laboratory tests showed iron deficiency. On gastroscopy, diffuse gastric and duodenal involvement was shown, characterized by a congested nodular mucosa with hypertrophy of gastric folds. Ileocolonoscopy demonstrated a mucosa with a cobblestone pattern and two inflammatory polyps. Biopsies pointed out an inflammatory infiltrate and abundant eosinophils in the lamina propria. Additionally, hyperplasia and foveolar dilation in the stomach, villous atrophy in the duodenum and crypt dilation in the colon were found [ 1 ] [ 2 ] [ 3 ]. All these findings were consistent with Cronkhite-Canada disease. Methylprednisolone 1 mg/kg was started with significant improvement. A descending regimen of corticosteroids and Azathioprine 125 mg/day prevented recurrences. Cronkhite-Canada disease is an acquired and uncommon entity. It typically presents in middle-aged individuals, with gastrointestinal and dermatological manifestations being most frequent. Gastrointestinal symptoms are often nonspecific. Over time, multiple gastrointestinal polyps typically develop, leading to a malabsorptive syndrome. Its pathophysiology is unknown, although an autoimmune base is suspected. Its prognosis is unfavorable, with a reported 5-year mortality rate of around 50%. Available treatments include systemic corticosteroids, immunosuppressants, budesonide and supportive care. This case has an unusual endoscopic manifestation, likely due to early diagnosis. Publication History Article published online: 27 March 2025 © 2025. European Society of Gastrointestinal Endoscopy. All rights reserved. Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".