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Dosimetric analysis of beam number variations in IMRT for head-and-neck, breast, and pelvic cancers using Halcyon

2025· article· en· W4408911741 on OpenAlexaff
Luong Tien Phat, Mai Thi Thao, Tran Trung Kien, Dương Thanh Tài, Peter Sandwall, Abdelmoneim Sulieman, Nissren Tamam, James C. L. Chow

Bibliographic record

VenueRadiation Physics and Chemistry · 2025
Typearticle
Languageen
FieldPhysics and Astronomy
TopicAdvanced Radiotherapy Techniques
Canadian institutionsPrincess Margaret Cancer CentreUniversity of TorontoUniversity Health Network
FundersPrincess Nourah Bint Abdulrahman University
KeywordsMedicineHead and neckNuclear medicineRadiologyOncologySurgery

Abstract

fetched live from OpenAlex

This study investigated the dosimetric effects of varying beam numbers (9, 11, and 13) in intensity-modulated radiation therapy (IMRT) using the Halcyon linear accelerator at ShingMark University Hospital. IMRT plans for 27 patients with head-and-neck, breast, and pelvic cancers were evaluated according to the RTOG 0615 protocol, focusing on Planning Target Volume (PTV) dose coverage, uniformity, maximum and minimum doses, and Organ-at-Risk (OAR) dose constraints. For breast cancer, the 11-beam plan improved PTV coverage (V50Gy: 97.9 ± 0.5 %) and reduced maximum dose compared to 9- and 13-beam plans, while the 13-beam plan lowered heart mean dose by up to 10.5 % in left breast cases. In pelvic cases, the 13-beam plan enhanced OAR sparing, reducing bowel V35Gy by 10.5 % compared to the 9-beam plan, with minimal PTV coverage differences (<0.2 %). For head-and-neck cancer, the 13-beam plan improved PTV D95 % and spared critical structures like the brainstem , though it increased doses to the chiasm and cochlea. Treatment time and Monitor Units rose with more beams, particularly for head-and-neck and pelvic cases, but remained minimal for breast cases. These findings suggest tailoring beam numbers to cancer type and clinical priorities, balancing dosimetric benefits with treatment efficiency.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.294
Teacher spread0.288 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes1
Has abstractyes

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