The Interaction Between <i>Ganoderma lucidum</i> Polysaccharides and Gut Microbiota: Implications for Immune Health
Bibliographic record
Abstract
Ganoderma lucidum polysaccharides (GLPs) are natural polysaccharide compounds extracted from Ganoderma lucidum, known for their diverse biological activities.This study explores the interaction between GLPs and gut microbiota and its effects on immune health, revealing how GLPs regulate immune responses through gut microbiota and investigating their potential applications in preventing and treating immune-related diseases.The study shows that GLPs can increase the production of short-chain fatty acids, regulate the proportion of beneficial gut bacteria, and alleviate inflammatory responses by modulating the TLR4/MyD88/NF-κB signaling pathway.The results indicate that GLPs significantly improve gut microbiota imbalance, enhance macrophage phagocytosis, and increase the cytotoxicity of natural killer cells, demonstrating their potential in immune regulation and disease prevention.Future research will focus on further uncovering the molecular mechanisms of GLPs and their long-term application potential in human health.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".