529 Clinical Performance of Synthetic Dermal Skin Substitute in 77 Patients
Bibliographic record
Abstract
Abstract Introduction Dermal skin substitutes are intended to compensate for the absence of dermal elements in traumatic wounds including severe burn injuries and are increasingly utilized in American Burn Centers. However, publications on the clinical performance of synthetic skin substitutes remain limited to small series or case reports. Furthermore, scarring outcomes after the two-step process of applying synthetic skin substitutes and split-thickness skin grafts (STSG) have hardly been studied at all. This IRB approved study was designed as a retrospective detailed assessment of the performance of synthetic skin substitutes, scarring outcomes, and their overall effectiveness in our center. Methods This study included all patients who underwent the two-stage wound closure procedure between 9/1/2017 and 2/28/2024. Patient electronic records were reviewed retrospectively. The evaluated data points included complications, as determined by infection and failure rates, the time delay between the application of the synthetic skin substitute and STSG, LOS after skin substitute placement, Vancouver Scar Scale (VSS) assessments, Patient and Observer Scar Assessment Scale (POSAS) questionnaires, and scar shrinkage measurements during follow up visits. All data were entered into RedCap® for analysis. Results The study included 77 patients and a total of 124 dermal synthetic skin substitute applications (122 synthetic biodegradable, 2 collagen based). All applications were analyzed, and the infection rate overall was 8.8%. The failure rate was found to be 3.2%. The time delay between the application date of the skin substitute and STSG averaged 28 days, to wound closure 35 days. The LOS after skin substitute averaged 45 days, after wound closure 10 days. Data on postoperative dressings (Silver 54.8%, VAC 38.7%), STSG thickness (0.0085), exposed structures in the wound etc. were also collected. 3-12 months post hospital discharge, the mean Vancouver scar scale rating was 8.39 out of 15, the mean Patient and Observer Scar Assessment Scale rating was 36.86 out of 60, and the median scar shrinkage was 2.89% of the initial wound size. Conclusions The usage of synthetic dermal skin substitute allows for a safe, reliable two-stage burn and wound closure. This burn/wound treatment exhibited minimal complications and long-term durability with acceptable scar formation and shrinkage. Applicability of Research to Practice Immediate Funding for the Study Institutional Burn research fund
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".