The rs243865 Polymorphism in Matrix Metalloproteinase-2 and its Association With Target Organ Damage in Patients With Resistant Hypertension: Cross-Sectional Study
Bibliographic record
Abstract
Background: Resistant hypertension (RH) presents significant clinical challenges, often precipitating a spectrum of cardiovascular complications. Particular attention recently has focused on the role of matrix metalloproteinase-2 (MMP-2) gene polymorphisms, implicated in hypertensive target organ damage (TOD). Despite growing interest, the specific contribution of MMP-2 polymorphisms to such damage in RH remains inadequately defined. Objective: This study is the first to examine the rs243865 (-1306C>T) polymorphism in the MMP-2 gene in the Vietnamese population and patients with RH, underscoring its critical role as a genetic determinant of TOD. Methods: A cross-sectional study with both descriptive and analytical components was conducted with 78 patients with RH at the Can Tho Central General Hospital and Can Tho University of Medicine and Pharmacy Hospital from July 2023 to February 2024. Results: More than three-quarters of patients with RH had carotid-femoral pulse wave velocity (PWV) >10 m/s and microalbuminuria at a prevalence of 79% (62/78) and 76% (59/78), respectively, and more than half of patients with RH had left ventricular mass index, relative wall thickness, and carotid artery stenosis with a prevalence of 56% (45/78), 55% (43/78), and 53% (41/78), respectively. Of the 78 studied patients with RH, the presence of genotype CC was 77% (60/78), genotype CT accounted for 21% (16/78), and genotype TT for 3% (2/78). The presence of single nucleotide polymorphism rs243865 (-1306C>T) with allele T was 23% (18/78). The MMP-2 gene polymorphism 1306C/T (rs243865) was significantly associated with ejection fraction and carotid artery stenosis with odds ratios (ORs) 8.1 (95% CI 1.3-51.4; P=.03) and 4.5 (95% CI 1.1-20.1; P=.048), respectively. The allele T was found to be significantly associated with arterial stiffness including brachial-ankle PWV and carotid-femoral PWV with the correlation coefficient of OR 2.2 (95% CI 0.6-3.8) and OR 1.8 (95% CI 0.5-3.2), respectively. Conclusions: The MMP-2 gene polymorphism rs243865 (-1306C>T) may have an association with measurable TOD in RH.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".