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Rethinking the Genomic Diversity Problem: Rejecting Inclusion in Defense of Indigenous Sovereignty

2025· review· en· W4409152887 on OpenAlexaff
Jessica Kolopenuk

Bibliographic record

VenueAnnual Review of Genomics and Human Genetics · 2025
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicRace, Genetics, and Society
Canadian institutionsUniversity of Alberta
Fundersnot available
KeywordsIndigenousDiversity (politics)Identity (music)SovereigntyEnvironmental ethicsInclusion (mineral)PoliticsSociologyEquity (law)ColonialismIdentity politicsPolitical scienceSocial scienceAnthropologyLawBiologyEcologyPhilosophy

Abstract

fetched live from OpenAlex

Interpretations of the so-called genomic diversity problem in precision medicine research reflect an enduring colonial logic tied to liberal identity/difference politics, prioritizing representational equity, diversity, and inclusion over substantive engagement with Indigenous sovereignties on their own ontological terms. This review critically analyzes not the underrepresentation of diverse populations in genomics but rather how the diversity problem is framed within genomics. It argues that liberal renderings of the diversity problem perpetuate colonizing knowledge production by reconstituting indigeneity as an identity/difference category. This review calls for a rejection of this reductive philosophical foundation in defense of Indigenous sovereignties and relationalities to transform scientific knowledge production.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesScience and technology studies
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.999
Threshold uncertainty score0.028

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.005
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0020.002
Science and technology studies0.0010.007
Scholarly communication0.0030.006
Open science0.0010.003
Research integrity0.0030.005
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.293
Teacher spread0.274 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designTheoretical or conceptual
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes1
Has abstractyes

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