Effects of ultrasound-assisted punicalagin binding on the allergenicity reduction of soybean protein 7S
Bibliographic record
Abstract
Punicalagin (PUN) is the predominant polyphenol in pomegranate peels, and it has antioxidant property. This study aimed to explore the potential of PUN binding in reducing the allergenicity of soybean protein 7S (a major soy allergen). Ultrasound pretreatment (U7S) was used to enhance the availability of PUN binding sites. After PUN binding, the U7S conformation became more disordered, and the surface hydrophobicity was reduced. The molecular docking results indicated that the formation of the U7S-PUN complexes mainly depended on hydrogen bonding interactions. The phenolic hydroxyl group from PUN endowed U7S with high antioxidant properties, which were retained after digestion in the gastrointestinal tract. At a molar ratio of 1:50, U7S-PUN complexes reduced the IgG binding capacity by approximately 58.05 % and increased the rate of degranulation inhibition to about 35.87 %. This research offers a theoretical foundation for the use of PUN in the production of hypoallergenic plant-based protein products.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".