Changes in Epidemiological Characteristics of Varicella and Breakthrough Cases in Ningbo, China, From 2010 to 2023: Surveillance Study
Bibliographic record
Abstract
Background: Varicella is a prevalent respiratory infectious disease. Continuous monitoring is essential to understand evolving epidemiological patterns, particularly given the impact of vaccination and recent nonpharmacological interventions. Objective: This study aims to monitor the epidemiological characteristics of varicella and the changes in breakthrough cases to inform adjustments in immunization strategies and enhance prevention efforts. Methods: From 2010 to 2023, varicella incidence was monitored using active (2010-2011) and passive (2012-2023) surveillance methods. Data were obtained from the Chinese Center for Disease Prevention and Control's information system and Ningbo's Immunization Information System. The study period was divided into four intervals to analyze trends. A birth cohort (2009-2013) was established to examine breakthrough cases. A recurrent neural network model was constructed for deep learning analysis of incidence trends and the impact of nonpharmaceutical interventions. Results: Between 2010 and 2023, a total of 70,163 varicella cases were reported in Ningbo. Seasonal distribution indicated two incidence troughs before 2020 and only one from 2020 to 2023. The predominant age of onset was 10-14 years, accounting for 23.93% (16,795/70,163) of cases. From 2010 to 2013, the highest incidence was among children aged 5-9 years; from 2014 to 2019, it shifted to those aged 10-14 years; and from 2020 to 2023, it was primarily among individuals aged 15-19 years. Following the introduction of a second vaccine dose (2014-2019), incidence among children younger than 10 years of age decreased, notably by 59.54% in those aged 1-4 years. Conversely, incidence among individuals aged 10 years and older increased, particularly by 123.78% in the 15-19 years age group, with a significant upward trend (Ptrend<.001). From 2020 to 2023, although incidence rates increased across age groups 15 years and older, the rise was modest. The average annual incidence rate of breakthrough cases after one vaccine dose was 83.40/100,000 (range, 51.21-119.50/100,000), significantly higher than the 24.80/100,000 (range, 17.67-32.90/100,000) observed after two doses. However, the incidence of breakthrough cases after the first dose declined following the implementation of the 2-dose program. The median time from vaccination to breakthrough case occurrence was 27 (IQR 17.50-48) months. The recurrent neural network model demonstrated high accuracy (mean squared error, 49.96) and indicated that implementation of emergency response and community lockdown measures in early 2020 correlated with a divergence between predicted and actual case numbers, suggesting an impact of nonpharmaceutical interventions on varicella transmission. Conclusions: The significant shifts in varicella epidemiology between 2010 and 2023 highlight the importance of continuous monitoring and proactive immunization adjustments. We recommend enhanced varicella surveillance focusing on adult populations, and a targeted increase in 2-dose vaccine coverage, particularly in high-risk environments such as high schools and universities.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".