TACE With Doxorubicin-Induced Cardiotoxicity
Bibliographic record
Abstract
Doxorubicin is an effective chemotherapeutic drug used in transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma. Although very effective, this molecule is known for its potential severe cardiotoxicity, which was the purpose for the development of drug-eluting beads-TACE that showed similar efficacy and improved safety. We present the case of a 58-year-old man with hepatocellular carcinoma who received 5 treatments of conventional TACE with doxorubicin and developed severe cardiotoxicity. Although the cardiotoxic effect of TACE with doxorubicin has already been reported in the literature, this case has serious implications, because the patient had to be removed from the liver transplant waitlist and this development could have been prevented. We believe that this complication of TACE should be more known, and hence more sought out. We also believe that drug-eluting beads-TACE should be preferred because it was proven safer in more frail patients.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".