Inflammatory targeted nanoplatform incorporated with antioxidative nano iron oxide to attenuate ulcerative colitis progression
Bibliographic record
Abstract
Antioxidative nanomaterials with reactive oxygen species (ROS) scavenging capabilities hold promise for the treatment of ulcerative colitis (UC). However, their clinical application is limited by rapid diffusion, susceptibility to inactivation, and insufficient targeting of inflammatory sites. This study focuses on developing a nanoplatform by integrating iron oxide nanoparticles (IONPs) into zeolitic imidazolate frameworks-8 (ZIF-8), termed as ZIF-8@IONPs. ZIF-8@IONPs exhibited good biocompatibility and effective ROS scavenging capabilities in RAW 264.7 cells. To enhance inflammatory targeting, HA@ZIF-8@IONPs were generated through hyaluronic acid (HA) surface modification. HA@ZIF-8@IONPs effectively reduced damage to intestinal tissues in the UC mouse model. Mechanistic revealed that HA@ZIF-8@IONPs exhibited antioxidant and anti-inflammatory activities by eliminating endogenous ROS, activating the Nrf2 signaling pathway, and inhibiting the NF-κB signaling pathway. This study highlights the nanoplatform's potential as a promising candidate for UC treatment due to its great targeting of inflammatory microenvironments and efficient ROS scavenging.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".