Abstract P3012: Increased Circulating Concentrations of Soluble Cell Adhesion Molecules and Fibrin-D-Dimer in Adults with Periodontal Disease
Bibliographic record
Abstract
Periodontal disease, specifically periodontitis, is a progressive multidimensional inflammatory disease of the oral cavity. In addition to adverse oral health consequences, periodontitis is associated with increased risk of atherothrombotic cardiovascular disease and events. Importantly, periodontitis affects >40% of adults in the United States over the age of 30 years. Despite improved management of many of the oral health consequences associated with periodontitis, factors that initiate and promote increased atherothrombotic risk and events are poorly understood. Elevated levels of circulating soluble cell adhesion molecules and fibrin D-dimer are markers of a proatherogenic vascular environment and strong prognostic indicators of atherothrombotic events. We tested the hypothesis that circulating levels of soluble cell adhesion molecules and fibrin D-dimer are elevated in adults with periodontitis, which, in turn, may contribute to the heightened risk of vascular disease and events in this population. Peripheral blood was collected from 26 middle-aged adults: 13 without periodontitis (9 M/4F; age: 49 + 3 yr; BMI: 28.5 + 0.9 kg/m 2 ) and 13 clinically diagnosed with periodontitis (7 M/6 F; 54 + 4 yr; 26.0 + 1.6 kg/m 2 ). All subjects were free of overt cardiovascular and metabolic disease. Plasma concentrations of extracellular soluble adhesion molecules (intracellular adhesion molecule-1 [sICAM-1], vascular adhesion molecule-1 [sVCAM-1], platelet endothelial cell adhesion molecule-1 [sPECAM-1] and E-selectin) and fibrin D-dimer were determined by immunoassay. sICAM-1 (265±14 vs 218±11 ng/mL), E-selectin (48±4 vs 36±3 ng/mL) and fibrin D-dimer (408±47 vs 278±31 ng/mL) were significantly higher (~25-50%) in adults with periodontitis. There were no significant group differences in either sVCAM-1 (595±38 vs 596±53 ng/mL) or sPECAM-1 (10±1 vs 9±1 ng/mL). Elevated circulating levels of sICAM and sE-selectin are sensitive biomarkers of vascular endothelial cell activation and adhesion and have been linked with increased risk of atherogenesis; in addition, elevated fibrin D-dimer is a direct indicator of thrombotic activity. Thus, the increased risk and prevalence of atherothrombotic events in adults with periodontitis may be mediated, in part, by increased expression of cell adhesion molecules and a prothrombotic environment as indicated by elevated soluble cell adhesion molecules and fibrin D-dimer levels.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".